Adenovirus (ADV) mainly affects the respiratory tract, but can infect multiple organs in the body. ADV infections mostly occur in children and around 10% of all childhood respiratory infections originate from ADV.
These infections are relatively mild in healthy children, but can be very serious in children who have been given a bone marrow transplant.
Similar to CMV-specific cells, ADV-specific T cells (Cytovir™ ADV) can also be isolated from a healthy donor and given to the infected patient. However, as ADV specific T cells are often not as frequent in the donor blood, these cells require expansion to manufacture a clinical dose. Cytovir ADV is currently under early clinical development.